These events can occur at any time during use and without warning symptoms. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.Gastrointestinal Bleeding, Ulceration, and Perforation Diclofenac sodium topical gel is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.This risk may occur early in treatment and may increase with duration of use. Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal.WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS
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